Enhancing the Potential of Cardiac Progenitor Cells
نویسندگان
چکیده
منابع مشابه
Enhancing the potential of cardiac progenitor cells: pushing forward with Pim-1.
There is no cure for ischemic heart disease; therefore, limiting damage and salvaging viable myocardium are the current gold standard for patient care. In recent years, much interest has surrounded the idea of cell-based myocardial regeneration as a therapeutic alternative to conventional treatment regimens. However, success in human trials using a variety of stem cells or progenitor-like cells...
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Background & Aims: Myocardial infarction is a leading cause of human mortality in industrialized and developing societies. Limited restorative ability of of cardiomyocytes after ischemic changes can causes extensive damage lead to prominent chronic heart failure. At present, the application of certain drugs is touted as one of the main available approaches to inhibit the spread of the lesion an...
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The very interesting paper by Tallini et al. (1) confirms our suggestion [derived from the study (2) of cardiospheres’ formation by cardiovascular precursors (CPs) isolated from the heart of embryonic, fetal, neonatal, and adult transgenic mice expressing GFP under the control of the c-kit promoter] that c-kit expression identifies in the heart CPs, differentiating into endothelial, cardiac, an...
متن کاملCardiac Progenitor Cells
In the last few years we have witnessed one of most extraordinary revolutions in cardiovascular medicine, namely, an explosion of basic and clinical studies that support the notion that the diseased heart can be repaired by administration of stem cells, resulting in formation of functional new myocytes and vessels. Although the mechanism by which cell therapy improves cardiac function and anato...
متن کاملResident Cardiac Progenitor Cells
Neufeld Cardiac Research Institute, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel Abstract Resident cardiac stem/progenitor cells are implicated in cell replacement, repair and maintenance of the myocardium. These cells are already committed to a specific cardiomyogenic pathway. Stimulation of these cells in injured hearts can open new options in cardiovascular regenerative...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2012
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.112.269183